Cognitive deficits in schizophrenia remain an unmet clinical need. Improved understanding
of the neuro-and psychopathology of these deficits depends on the availability of carefully …

During brain maturation, the occurrence of the extracellular matrix (ECM) terminates juvenile
plasticity by mediating structural stability. Interestingly, enzymatic removal of the ECM …

Current literature lacks consolidated evidence for the impact of stimulation parameters on
the effects of transcranial direct current stimulation (tDCS) in enhancing upper limb motor …

Potentiation of metabotropic glutamate receptor subtype 5 (mGluR5) function produces
antipsychotic-like and pro-cognitive effects in animal models of schizophrenia and can …

In an ever-changing environment, the ability to adapt choices to new conditions is essential
for daily living and ultimately, for survival. Behavioural flexibility allows animals to maximise …

Glutamate abnormalities in the medial prefrontal cortex (mPFC) are associated with
cognitive deficits. We previously showed that homozygous deletion of CNS glutamate …

In the novel object recognition (OR) paradigm, rats are placed in an arena where they
encounter two sample objects during a familiarization phase. A few minutes later, they are …

Background Repetitive behavior is a term used to describe a wide variety of invariant and
inappropriate behaviors that occur in many diverse conditions, including autism. It is …

Schizophrenia is a chronic and devastating illness. Exact causes of the disease remain
elusive; however, neurodevelopmental changes in the brain glutamate system are …

Patients with schizophrenia often manifest deficits in behavioral flexibility. Non-competitive
NMDA receptor antagonists such as MK-801 induce schizophrenia-like symptoms in …