Neurodegenerative disorders (NDs) include a range of chronic conditions characterized by
progressive neuronal loss, leading to cognitive, motor, and behavioral impairments …

Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …

Some neurodegenerative diseases may be characterized by continuing behavioral and
cognitive dysfunction that encompasses memory loss and/or apathy. Alzheimer's disease is …

The pathogenesis of epilepsy remains unclear; however, a prevailing hypothesis suggests
that the primary underlying cause is an imbalance between neuronal excitability and …

Metal ions can perform multiple roles ranging from regulatory to structural and are crucial for
cell function. While some metal ions like Na+ are ubiquitously present at high …

Glycine plays a pivotal role in the Central Nervous System (CNS), being a major inhibitory
neurotransmitter as well as a co-agonist of Glutamate at excitatory NMDA receptors …

Non-small cell lung cancer (NSCLC) is the predominant subtype of lung cancer. Evidence
suggests that the ionotropic glutamate receptor N-methyl-D-aspartate (NMDA) receptor, a …

Alzheimer's disease (AD) is a prevalent and debilitating brain disorder that worsens
progressively with age, characterized by cognitive decline and memory impairment. The …

N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptors
critical for synaptic transmission and plasticity, and for the development of neural circuits …

The aberrant formation and function of neuronal synapses are recognized as major
phenotypes in many cases of neurodevelopmental (NDDs) and-psychiatric disorders …