Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …

Neuroblastoma is the most common extracranial solid tumor in childhood accounting for 8–
10% of all childhood malignancies. The tumor is characterized by a spectrum of …

Adverse prognosis in Ewing sarcoma (ES) is associated with the presence of metastases,
particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic …

Purpose: Psychologic depression has been shown to dysregulate the immune system and
promote tumor progression. The aim of this study is to investigate how psychologic …

Emerging evidence suggests that nerves within the tumor microenvironment play a crucial
role in regulating angiogenesis. Neurotransmitters and neuropeptides released by nerves …

Currently available data on the involvement of neuropeptide Y (NPY), peptide YY (PYY), and
pancreatic polypeptide (PP) and their receptors (YRs) in cancer are updated. The structure …

Background Cancer stroma contains the neural compartment with specific components and
action. Neural microenvironment processing includes among others axonogenesis …

Abstract Purpose Neuropeptide Y (NPY) is a pleiotropic peptide, which is involved in many
biological mechanisms important in regulation of cell growth and survival. The aim of this …

Brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor TrkB have been
reported to be associated with poor prognosis in neuroblastoma (NB) patients. Our previous …

Neuropeptide Y (NPY) is a sympathetic neurotransmitter with pleiotropic actions, many of
which are highly relevant to tumor biology. Consequently, the peptide has been implicated …