Principles of DNA methylation and their implications for biology and medicine

Y Dor, H Cedar - The Lancet, 2018 - thelancet.com
DNA methylation represents an annotation system for marking the genetic text, thus
providing instruction as to how and when to read the information and control transcription …

Hormonal regulation of mammary gland development and lactation

FM Hannan, T Elajnaf, LN Vandenberg… - Nature Reviews …, 2023 - nature.com
Lactation is critical to infant short-term and long-term health and protects mothers from
breast cancer, ovarian cancer and type 2 diabetes mellitus. The mammary gland is a …

[HTML][HTML] Stem cells and the differentiation hierarchy in mammary gland development

NY Fu, E Nolan, GJ Lindeman… - Physiological …, 2020 - journals.physiology.org
The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

[HTML][HTML] A human breast atlas integrating single-cell proteomics and transcriptomics

GK Gray, CMC Li, JM Rosenbluth, LM Selfors… - Developmental cell, 2022 - cell.com
The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

[HTML][HTML] Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing

K Bach, S Pensa, M Grzelak, J Hadfield… - Nature …, 2017 - nature.com
Characterising the hierarchy of mammary epithelial cells (MECs) and how they are
regulated during adult development is important for understanding how breast cancer …

[HTML][HTML] Aging-associated alterations in mammary epithelia and stroma revealed by single-cell RNA sequencing

CMC Li, H Shapiro, C Tsiobikas, LM Selfors, H Chen… - Cell reports, 2020 - cell.com
Aging is closely associated with increased susceptibility to breast cancer, yet there have
been limited systematic studies of aging-induced alterations in the mammary gland. Here …

25 years of research in human lactation: from discovery to translation

DT Geddes, Z Gridneva, SL Perrella, LR Mitoulas… - Nutrients, 2021 - mdpi.com
Researchers have recently called for human lactation research to be conceptualized as a
biological framework where maternal and infant factors impacting human milk, in terms of …

[HTML][HTML] The molecular basis of mammary gland development and epithelial differentiation

PF Slepicka, AVH Somasundara… - Seminars in cell & …, 2021 - Elsevier
Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

Umap and Bismap: quantifying genome and methylome mappability

M Karimzadeh, C Ernst, A Kundaje… - Nucleic acids …, 2018 - academic.oup.com
Short-read sequencing enables assessment of genetic and biochemical traits of individual
genomic regions, such as the location of genetic variation, protein binding and chemical …

Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands

HK Lee, M Willi, C Liu, L Hennighausen - Nature Communications, 2023 - nature.com
Regulation of high-density loci harboring genes with different cell-specificities remains a
puzzle. Here we investigate a locus that evolved through gene duplication and contains …