Myofibrillogenesis in striated muscles is a highly complex process that depends on the
coordinated assembly and integration of a large number of contractile, cytoskeletal, and …

The sarcomere is the basic unit of the myofibrils, which mediate skeletal and cardiac Muscle
contraction. Two transverse structures, the Z-disc and the M-band, anchor the thin (actin and …

In C. elegans, mutants that are defective in muscle function and/or structure are easy to
detect and analyze since: 1) body wall muscle is essential for locomotion, and 2) muscle …

This is the first of a projected series of canonic reviews covering all invertebrate muscle
literature prior to 2005 and covers muscle genes and proteins except those involved in …

The giant protein obscurin is thought to link the sarcomere with the sarcoplasmic reticulum
(SR). The N-terminus of obscurin interacts with the M-band proteins titin and myomesin …

Sarcomeres consist of highly ordered arrays of thick myosin and thin actin filaments along
with accessory proteins. Thick filaments occupy the center of sarcomeres where they …

Obscurin (~ 800 kDa) in striated muscle closely surrounds sarcomeres at the level of the M‐
band and Z‐disk where, we hypothesize, it participates in the assembly of the contractile …

Background Tenascins are a family of glycoproteins found primarily in the extracellular
matrix of embryos where they help to regulate cell proliferation, adhesion and migration. In …

Obscurin (also known as Unc-89 in Drosophila) is a large modular protein in the M-line of
Drosophila muscles. Drosophila obscurin is similar to the nematode protein UNC-89. Four …

Lamins form structural filaments in the nucleus. Mutations in A-type lamins cause muscular
dystrophy, cardiomyopathy and other diseases, including progeroid syndromes. To identify …