On the normative advantages of dopamine and striatal opponency for learning and choice

A Jaskir, MJ Frank - Elife, 2023 - elifesciences.org
The basal ganglia (BG) contribute to reinforcement learning (RL) and decision-making, but
unlike artificial RL agents, it relies on complex circuitry and dynamic dopamine modulation …

Serotonin predictively encodes value

EF Harkin, CD Grossman, JY Cohen, JC Béïque… - bioRxiv, 2023 - biorxiv.org
The in vivo responses of dorsal raphe nucleus (DRN) serotonin neurons to emotionally-
salient stimuli are a puzzle. Existing theories centred on reward, surprise, or uncertainty …

[HTML][HTML] An opponent striatal circuit for distributional reinforcement learning

AS Lowet, Q Zheng, M Meng, S Matias, J Drugowitsch… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Abstract Machine learning research has achieved large performance gains on a wide range
of tasks by expanding the learning target from mean rewards to entire probability …

Policy complexity suppresses dopamine responses

SJ Gershman, A Lak - Journal of Neuroscience, 2025 - jneurosci.org
Limits on information processing capacity impose limits on task performance. We show that
male and female mice achieve performance on a perceptual decision task that is near …

Making Sense of Serotonin Through Spike Frequency Adaptation

E Harkin - 2023 - ruor.uottawa.ca
What does serotonin do? Just as the diffuse axonal arbours of midbrain serotonin neurons
touch nearly every corner of the forebrain, so too is this ancient neuromodulator involved in …