Targeting carbonic anhydrases for the management of hypoxic metastatic tumors
CT Supuran - Expert Opinion on Therapeutic Patents, 2023 - Taylor & Francis
Introduction Several isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1)
are connected with tumorigenesis. Hypoxic tumors overexpress CA IX and XII as a …
are connected with tumorigenesis. Hypoxic tumors overexpress CA IX and XII as a …
The role of the sulfaguanidine molecular scaffold in drug design and development
HS Abulkhair - Archiv der Pharmazie, 2024 - Wiley Online Library
Developing new molecular entities is one of the most emerging research areas in the field of
Medicinal Chemistry. Over the past few years, rigorous research has been conducted on …
Medicinal Chemistry. Over the past few years, rigorous research has been conducted on …
Recyclization of morpholinochromonylidene–thiazolidinone using nucleophiles: facile synthesis, cytotoxic evaluation, apoptosis, cell cycle and molecular docking …
TE Ali, MA Assiri, MN Alqahtani, AA Shati, MY Alfaifi… - RSC …, 2023 - pubs.rsc.org
A convenient synthetic approach for construction of a novel series of substituted azoles,
azines, azepines and pyrans clubbed with a morpholinothiazolidinone hybrid was achieved …
azines, azepines and pyrans clubbed with a morpholinothiazolidinone hybrid was achieved …
Sulfaguanidines: A new class of carbonic anhydrase inhibitors
AK Obaid Aldulaimi, EA Mahmood… - Medicinal and Medical …, 2024 - medmedchem.com
This review is an attempt to summarize recent pioneering studies in the biological
assessment of sulfaguanidine-conatining compounds as carbonic anhydrase inhibitors …
assessment of sulfaguanidine-conatining compounds as carbonic anhydrase inhibitors …
Synthesis and carbonic anhydrase I, II, IX, and XII inhibition studies with a series of cyclic sulfonyl guanidines
A series of thirteen cyclic sulfonyl guanidines were prepared and evaluated against tumor‐
associated human (h) carbonic anhydrase (CA, EC 4.2. 1.1) isoforms hCA IX and hCA XII, as …
associated human (h) carbonic anhydrase (CA, EC 4.2. 1.1) isoforms hCA IX and hCA XII, as …
In‐vitro and in‐silico investigations of SLC‐0111 hydrazinyl analogs as human carbonic anhydrase I, II, IX, and XII inhibitors
Two novel series of hydrazinyl‐based benzenesulfonamides 9a–j and 10a–j were designed
and synthesized using SLC‐0111 as the lead molecule. The newly synthesized compounds …
and synthesized using SLC‐0111 as the lead molecule. The newly synthesized compounds …