Introduction VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome
is a recently described, late-onset, acquired autoinflammatory disorder caused by mutations …

Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …

Importance VEXAS (vacuoles, E1-ubiquitin-activating enzyme, X-linked, autoinflammatory,
somatic) syndrome is a disease with rheumatologic and hematologic features caused by …

Somatic mutations in UBA1 cause vacuoles, E1 ubiquitin-activating enzyme, X-linked,
autoinflammatory somatic (VEXAS) syndrome, an adult-onset inflammatory disease with an …

Acquired mutations in the UBA1 gene were recently identified in patients with severe adult-
onset auto-inflammatory syndrome called VEXAS (vacuoles, E1 enzyme, X-linked …

Objectives To evaluate the effectiveness and safety of current treatment strategies for the
vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome. Methods A …

Objective Somatic mutations in UBA1 have recently been causally linked to a severe adult‐
onset inflammatory condition referred to as VEXAS (vacuoles, E1 enzyme, X‐linked …

Several editions of the World Health Organization (WHO) classifications of lympho‐
hemopoietic neoplasms in 2001, 2008, and 2016 served as the international standard for …

Abstract VEXAS (Vacuoles, E1 enzyme, X‐linked, Autoinflammatory, Somatic) syndrome is a
newly identified disease caused by somatic alterations in UBA1 which produce a recalcitrant …

Vasculitis is an inflammatory disorder of the blood vessels that causes damage to a wide
variety of organs through tissue ischemia. Vasculitis is classified according to the size (large …