The daily alternation between sleep and wakefulness is one of the most dominant features
of our lives and is a manifestation of the intrinsic 24 h rhythmicity underlying almost every …

The molecular circadian timing system involves genes known as “clock genes,” such as the
PER3 gene. Studies have demonstrated associations among a repeat polymorphism …

Study Objectives: A recent clinical trial demonstrated that melatonin treatment was effective
in improving self-perceived sleep quality in patients with traumatic brain injury (TBI); …

Background Changes in circadian rhythm are related to various diseases, such as immune
system diseases and cardiovascular diseases. The PERIOD3 (PER3) clock gene is one of …

This chapter focuses on genotype-driven interindividual differences in phenotypic
neurobehavioral responses to different types of sleep loss, including sleep restriction and …

Circadian rhythm issues are common and can impact health and quality of life. Delayed
sleep-wake phase disorder (DSWPD) is characterized by late bedtime and wake times and …