Breast cancer, a most common malignancy in women, was known to be associated with
steroid hormone estrogen. The discovery of estrogen receptor (ER) gave us not only a …

Chemical transformations that introduce, remove or manipulate functional groups are
ubiquitous in synthetic chemistry. Unlike conventional functional-group interconversion …

Abstract Two (4-hydroxyphenyl) substituted polycyclic carbocycles were prepared and
assayed for estrogen receptor activity. 4-(4-Hydroxyphenyl) tricyclo [3.3. 1.1 3, 7] decane-1 …

Estrogen receptors (ER) are nuclear hormone receptors which are responsible for sex
hormone signaling in women. A series of (1, 4-disubstituted)-1, 2, 3-triazoles 5–21 were …

Disclosed are 4-hydroxylphenyl substituted carbocycles and there use as selective agonists
of the estrogen receptor beta isoform (ERβ). The disclosed compounds may be formulated …