BGC Atlas: a web resource for exploring the global chemical diversity encoded in bacterial genomes

C Bağcı, M Nuhamunada, H Goyat… - Nucleic acids …, 2025 - academic.oup.com
Secondary metabolites are compounds not essential for an organism's development, but
provide significant ecological and physiological benefits. These compounds have …

Targeted discovery of cryptic metabolites with antiproliferative activity

EJ Han, SR Lee, S Hoshino… - ACS chemical …, 2022 - ACS Publications
Microorganisms have provided a rich source of therapeutically valuable natural products.
Recent advances in whole genome sequencing and bioinformatics have revealed immense …

Long-read metagenome-assembled genomes improve identification of novel complete biosynthetic gene clusters in a complex microbial activated sludge ecosystem

R Sánchez-Navarro, M Nuhamunada, OS Mohite… - Msystems, 2022 - Am Soc Microbiol
Microorganisms produce a wide variety of secondary/specialized metabolites (SMs), the
majority of which are yet to be discovered. These natural products play multiple roles in …

Small spatial scale drivers of secondary metabolite biosynthetic diversity in environmental microbiomes

AU Geers, ML Strube, M Bentzon-Tilia - Msystems, 2023 - Am Soc Microbiol
In the search for novel drug candidates, diverse environmental microbiomes have been
surveyed for their secondary metabolite biosynthesis potential, yet little is known about the …

Microbiome science of human excrement composting

J Meilander, JG Caporaso - The ISME Journal, 2024 - academic.oup.com
Linear waste management systems are unsustainable and contribute to environmental
degradation, economic inequity, and health disparities. Among the array of environmental …

Fructooligosaccharides (FOS) Production by Microorganisms with Fructosyltransferase Activity

Y Belmonte-Izquierdo, LF Salomé-Abarca… - Fermentation, 2023 - mdpi.com
Fructans are fructose-based polymers, defined as fructooligosaccharides (FOS), when they
possess a short chain. These molecules are highly appreciated in the food and …

Genome-resolved metagenomics of Venice Lagoon surface sediment bacteria reveals high biosynthetic potential and metabolic plasticity as successful strategies in …

E Banchi, E Corre, P Del Negro, M Celussi… - Marine Life Science & …, 2024 - Springer
Bacteria living in sediments play essential roles in marine ecosystems and deeper insights
into the ecology and biogeochemistry of these largely unexplored organisms can be …

SecMet-FISH: labeling, visualization, and enumeration of secondary metabolite producing microorganisms

Y Buijs, AU Geers, I Nita, ML Strube… - FEMS Microbiology …, 2024 - academic.oup.com
Our understanding of the role of secondary metabolites in microbial communities is
challenged by intrinsic limitations of culturing bacteria under laboratory conditions and …

Exploring the biosynthesis potential of permafrost microbiomes

AU Geers, Y Buijs, MD Schostag, B Elberling… - Environmental …, 2024 - Springer
Background Permafrost microbiomes are of paramount importance for the biogeochemistry
of high latitude soils and while endemic biosynthetic domain sequences involved in …

RibDif2: expanding amplicon analysis to full genomes

R Murphy, ML Strube - Bioinformatics Advances, 2023 - academic.oup.com
Motivation As previously described, amplicon analysis of the bacterial 16S gene has several
limitations owing to fundamental characteristics of both the 16S gene and technological …