In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …

In gastric cancer (GC) the loss of genomic stability represents a key molecular step that
occurs early in the carcinogenesis process and creates a permissive environment for the …

Gastric cancer is the second most frequent cause of cancer death worldwide, although much
geographical variation in incidence exists. Prevention and personalised treatment are …

Utilizing the concept of synthetic lethality has provided new opportunities for the
development of targeted therapies, by allowing the targeting of loss of function genetic …

The DNA repair pathways help to maintain genomic integrity and therefore genetic variation
in the pathways could affect the propensity to develop cancer. Selected germline single …

Unravelling the molecular mechanisms underlying gastric carcinogenesis is one of the
major challenges in cancer genomics. Gastric cancer is a very complex and heterogeneous …

Gastric cancer is one of the leading causes of cancer death worldwide, and although the
incidence has decreased in Western countries, specific high-risk areas are present in Italy …

Gastric cancer is one of the leading causes of cancer-related deaths worldwide, although
the incidence has gradually decreased in many Western countries. Two main gastric cancer …

We have identified new genomic alterations in the breast cancer cell line HCC1954, using
high-throughput transcriptome sequencing. With 120 Mb of cDNA sequences, we were able …

Currently, gastric cancer (GC) is one of the most frequently diagnosed neoplasms, with a
global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death …