Alzheimer's disease (AD) starts from pure cognitive impairments and gradually progresses
into degeneration of specific brain circuits. Although numerous factors initiating AD have …

Abstract γ-Secretase cleavage is essential for many biological processes and its
dysregulation is linked to disease, including cancer and Alzheimer's disease. Therefore …

Presenilin (PSEN)/γ-secretase is a protease complex responsible for the proteolytic
processing of numerous substrates. These substrates include the amyloid precursor protein …

The rising prevalence of Alzheimer's disease (AD), together with the lack of effective
treatments, portray it as one of the major health challenges of our times. Untangling AD …

Although dysautonomia was documented in inflammatory bowel disease, with activation of
the stress-related sympathetic system, the role of agonists/antagonists of the adrenergic …

Alzheimer's disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ),
which is generated through sequential proteolysis of the amyloid precursor protein (APP) …

Amyloid β (Aβ) peptides accumulating in the brain are proposed to trigger Alzheimer's
disease (AD). However, molecular cascades underlying their toxicity are poorly defined …

Objective Mutations in presenilin genes are the major cause of Alzheimer's disease.
However, little is known about their expression and function in the gut. In this study, we …

Abstract Presenilin 1 (PS1) is a catalytic component of the γ-secretase complex, responsible
for the intramembraneous cleavage of more than 90 type I transmembrane proteins …

A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42
peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β-and …