Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …

Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Major psychiatric disorders are heritable but they are genetically complex. This means that,
with certain exceptions, single gene markers will not be helpful for diagnosis. However, we …

Genomewide association studies (GWASs) across psychiatric phenotypes have shown that
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …

The outcome of first-episode psychosis (FEP) is highly variable, ranging from early
sustained recovery to antipsychotic treatment resistance from the onset of illness. For …

Psychotic disorders affect 3% of the population at some stage in life, are a leading cause of
disability, and impose a great economic burden on society. Major breakthroughs in the …

Genetic testing has evolved rapidly over recent years and new developments have the
potential to provide insights that could improve the ability to diagnose, treat, and prevent …

Background Major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia
(SCZ) share clinical features and genetic bases. Magnetic Resonance Imaging (MRI) …

Cognitive deficit is thought to represent, at least in part, genetic mechanisms of risk for
schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct …

Schizophrenia has a multifactorial etiology, involving a polygenic architecture. The potential
benefit of whole genome sequencing (WGS) in schizophrenia and other psychotic disorders …