Polyploidy has been hypothesized to be both an evolutionary dead-end and a source for
evolutionary innovation and species diversification. Although polyploid organisms …

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …

Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

Polyploidy, or the duplication of entire genomes, has been observed in prokaryotic and
eukaryotic organisms, and in somatic and germ cells. The consequences of polyploidization …

Polyploidy, resulting from the duplication of the entire genome of an organism or cell, greatly
affects genes and genomes, cells and tissues, organisms, and even entire ecosystems …

Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …

Whole-genome doubling (WGD) is common in human cancers, occurring early in
tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour …

Metastatic cancer is a major cause of death and remains largely incurable. A better
understanding of metastasis is therefore desperately needed to improve prognosis for late …