The biology of ergothioneine, an antioxidant nutraceutical

I Borodina, LC Kenny, CM McCarthy… - Nutrition Research …, 2020 - cambridge.org
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …

Glucose repression in Saccharomyces cerevisiae

Ö Kayikci, J Nielsen - FEMS yeast research, 2015 - academic.oup.com
Glucose is the primary source of energy for the budding yeast Saccharomyces cerevisiae.
Although yeast cells can utilize a wide range of carbon sources, presence of glucose …

[HTML][HTML] De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

M Li, KR Kildegaard, Y Chen, A Rodriguez… - Metabolic …, 2015 - Elsevier
Resveratrol is a natural antioxidant compound, used as food supplement and cosmetic
ingredient. Microbial production of resveratrol has until now been achieved by …

YEASTRACT+: a portal for the exploitation of global transcription regulation and metabolic model data in yeast biotechnology and pathogenesis

MC Teixeira, R Viana, M Palma, J Oliveira… - Nucleic Acids …, 2023 - academic.oup.com
Abstract YEASTRACT+ (http://yeastract-plus. org/) is a tool for the analysis, prediction and
modelling of transcription regulatory data at the gene and genomic levels in yeasts. It …

Reconstruction of a catalogue of genome-scale metabolic models with enzymatic constraints using GECKO 2.0

I Domenzain, B Sánchez, M Anton… - Nature …, 2022 - nature.com
Genome-scale metabolic models (GEMs) have been widely used for quantitative exploration
of the relation between genotype and phenotype. Streamlined integration of enzyme …

[HTML][HTML] Establishment of a yeast platform strain for production of p-coumaric acid through metabolic engineering of aromatic amino acid biosynthesis

A Rodriguez, KR Kildegaard, M Li, I Borodina… - Metabolic …, 2015 - Elsevier
Aromatic amino acids are precursors of numerous plant secondary metabolites with diverse
biological functions. Many of these secondary metabolites are already being used as active …

EasyClone‐MarkerFree: A vector toolkit for marker‐less integration of genes into Saccharomyces cerevisiae via CRISPR‐Cas9

MM Jessop‐Fabre, T Jakočiūnas… - Biotechnology …, 2016 - Wiley Online Library
Saccharomyces cerevisiae is an established industrial host for production of recombinant
proteins, fuels and chemicals. To enable stable integration of multiple marker‐free …

Carbon catabolite repression in filamentous fungi

M Adnan, W Zheng, W Islam, M Arif… - International Journal of …, 2017 - mdpi.com
Carbon Catabolite Repression (CCR) has fascinated scientists and researchers around the
globe for the past few decades. This important mechanism allows preferential utilization of …

CRISPR/Cas system for yeast genome engineering: advances and applications

V Stovicek, C Holkenbrink, I Borodina - FEMS yeast research, 2017 - academic.oup.com
The methods based on the clustered regularly interspaced short palindromic repeats
(CRISPR)/CRISPR-associated (Cas) system have quickly gained popularity for genome …

DCEO biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals

X Chen, C Gao, L Guo, G Hu, Q Luo, J Liu… - Chemical …, 2018 - ACS Publications
Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …