[HTML][HTML] Roles of lncRNAs in the transcription regulation of HIV-1

X Liu, M Xu, P Li, W Zhang, L Zeng, Y Yang, G Yang - biomedical journal, 2022 - Elsevier
Abstract Long noncoding RNAs (LncRNAs) is a class of RNA molecules that are more than
200bp but cannot be translated into proteins. More and more studies have proved that …

Epigenetic mechanisms of HIV-1 persistence

R Verdikt, O Hernalsteens, C Van Lint - Vaccines, 2021 - mdpi.com
Eradicating HIV-1 in infected individuals will not be possible without addressing the
persistence of the virus in its multiple reservoirs. In this context, the molecular …

RNet: a network strategy to predict RNA binding preferences

H Liu, Y Jian, J Hou, C Zeng… - Briefings in Bioinformatics, 2024 - academic.oup.com
Determining the RNA binding preferences remains challenging because of the bottleneck of
the binding interactions accompanied by subtle RNA flexibility. Typically, designing RNA …

Non-coding RNAs in the etiology and control of major and neglected human tropical diseases

O Tamgue, CF Mezajou, NN Ngongang… - Frontiers in …, 2021 - frontiersin.org
Non-coding RNAs (ncRNAs) including microRNAs (miRs) and long non-coding RNAs
(lncRNAs) have emerged as key regulators of gene expression in immune cells …

An evaluation on the role of non-coding RNA in HIV transcription and latency: a review

PW Ramirez, C Pantoja… - HIV/AIDS-Research and …, 2023 - Taylor & Francis
The existence of latent cellular reservoirs is recognized as the major barrier to an HIV cure.
Reactivating and eliminating “shock and kill” or permanently silencing “block and lock” the …

[HTML][HTML] Roles and potential applications of lncRNAs in HIV infection

L Shen, C Wu, J Zhang, H Xu, X Liu, X Wu… - International Journal of …, 2020 - Elsevier
Long non-coding RNAs (lncRNAs) are defined as a class of RNA molecules with a length of
more than 200 nucleotides that are not translated into protein, and are known to participate …

Improved Cas9 activity by specific modifications of the tracrRNA

T Scott, R Urak, C Soemardy, KV Morris - Scientific Reports, 2019 - nature.com
CRISPR/Cas is a transformative gene editing tool, that offers a simple and effective way to
target a catalytic Cas9, the most widely used is derived from Streptococcus pyogenes (Sp …

Extracellular vesicles from infected cells are released prior to virion release

Y Kim, GA Mensah, S Al Sharif, DO Pinto, H Branscome… - Cells, 2021 - mdpi.com
Here, we have attempted to address the timing of EV and virion release from virally infected
cells. Uninfected (CEM), HIV-1-infected (J1. 1), and human T cell leukemia virus-1 (HTLV-1) …

Assessment of anti-HIV-1 guide RNA efficacy in cells containing the viral target sequence, corresponding gRNA, and CRISPR/Cas9

AG Allen, CH Chung, SD Worrell, G Nwaozo… - Frontiers in genome …, 2023 - frontiersin.org
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 gene
editing system has been shown to be effective at inhibiting human immunodeficiency virus …

The TAR binding dynamics and its implication in tat degradation mechanism

S Ning, C Zeng, C Zeng, Y Zhao - Biophysical Journal, 2021 - cell.com
Human immunodeficiency virus (HIV) is a retrovirus that progressively attacks the human
immune system. It is known that the HIV viral protein Tat recruits the host elongation factor …