Abstract Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic
disease characterized by segmental premature aging, with cardiovascular disease being the …

Eukaryotic cells continuously experience DNA damage that can perturb key molecular
processes like DNA replication. DNA replication forks that encounter DNA lesions typically …

The DNA damage response (DDR) and the blood-tumor barrier (BTB) restrict
chemotherapeutic success for primary brain tumors like glioblastomas (GBMs). Coherently …

Regulatory T cells (Tregs) suppress the activity of effector T, B and NK lymphocytes and
sustain immunological tolerance, but the proliferative activity of suppressed cells remains …

Regulatory T cells (Tregs) participate in the negative regulation of inflammatory reactions by
suppressing effector cells. In a number of autoimmune disorders, the suppressive function …

Metformin is a classic type II diabetes drug which possesses anti-tumor properties for
various cancers. However, different cancers do not respond to metformin with the same …

Aims The functions and molecular mechanisms of miR-340-3p in lung adenocarcinoma
(LUAD) progression remain unclear. On the other hand, the role of HUS1 in LUAD …

目的本研究旨在探索构建一个基于DNA 损伤修复相关基因(DDRGs) 的预测膀胱癌患者生存
预后及免疫治疗效果的风险模型. 方法首先, 从TCGA-BLCA 数据集下载的RNA 序列及临床信息 …

Platinum-based chemotherapy is the standard of care with concern to first-line systemic
therapy for metastatic disease in urothelial cancer (UC). Resistance to chemotherapy …

Pathologic downstaging (pDS) to neoadjuvant chemotherapy (NAC) is one of the most
important predictors of survival in muscle-invasive bladder cancer (MIBC). The use of NAC is …