Irradiation of pharmaceuticals: A literature review

GP Jacobs - Radiation Physics and Chemistry, 2022 - Elsevier
Regulatory authorities require pharmaceuticals to be sterilized wherever practicable by a
terminal sterilization method that is sterilized in the final container rather than by aseptic …

Paramagnetic characterization and dosimetric properties of Airfix drug and its ingredients (Montelukast sodium, Sorbitol): An EPR and DFT study

E Ece, HU Tasdemir, R Biyik, A Ozmen… - Radiation Physics and …, 2022 - Elsevier
In this study, radiation effect on an asthma drug Airfix and its ingredients (Montelukast
sodium, Sorbitol) were analyzed by using EPR spectroscopy in the dose range of 10 Gy–30 …

Electron spin resonance identification of irradiated ascorbic acid: dosimetry and influence of powder fineness

JP Basly, I Basly, M Bernard - Analytica chimica acta, 1998 - Elsevier
As an alternative to heat and gas exposure sterilization, ionizing radiation is gaining interest
for sterilization of medicinal products. Detection and dosimetry of pharmaceuticals …

ESR spectroscopy applied to the study of pharmaceuticals radiosterilization: cefoperazone

JP Basly, I Basly, M Bernard - Journal of pharmaceutical and biomedical …, 1998 - Elsevier
As an alternative to heat and gas exposure sterilization, ionizing radiation is gaining interest
as a sterilization process for medicinal products. Nevertheless, essentially for economic …

Some recent developments of EPR dosimetry

ND Yordanov, V Gancheva, Y Karakirova - EPR of Free Radicals in Solids …, 2012 - Springer
In the last three decades EPR spectrometry has expanded significantly in the field of
practical applications. This is mainly due to its high sensitivity (10 12–10 13 molecules …

ESR identification of radiosterilized pharmaceuticals: latamoxef and ceftriaxone

JP Basly, I Longy, M Bernard - International journal of pharmaceutics, 1997 - Elsevier
As an alternative to heat and gas exposure sterilization, ionizing radiation is gaining interest
as a sterilization process for medicinal products. The aim of this work was to develop …

Radiosterilization dosimetry by electron-spin resonance spectroscopy: Cefotetan

JP Basly, I Longy, M Bernard - Analytica chimica acta, 1998 - Elsevier
As an alternative to heat and gas exposure sterilization, ionizing radiation is gaining interest
as a sterilization process for medicinal products. Nevertheless, essentially for economic …

EPR investigation of some gamma-irradiated excipients

K Aleksieva, ND Yordanov - Radiation Effects and Defects in Solids, 2012 - Taylor & Francis
The results of electron paramagnetic resonance (EPR) studies on some excipients: lactose,
microcrystalline cellulose (avicel), starch, dioxosilane (aerosil), talc and magnesium stearate …

Study on gamma and electron beam sterilization of third generation cephalosporins cefdinir and cefixime in solid state

BK Singh, DV Parwate, IBD Sarma… - Radiation Physics and …, 2010 - Elsevier
The effect of gamma radiation from 60Co source and 2MeV e-beam was studied on two
thermolabile cephalosporin antibiotics viz cefdinir and cefixime in solid state. The …

Effects of gamma-irradiation on trehalose–hydroxyethylcellulose microspheres loaded with vancomycin

A Bartolotta, MC D'Oca, M Campisi, V De Caro… - European Journal of …, 2005 - Elsevier
Ionizing radiation can be used as a drug sterilization technique, provided that the drug itself
is not modified and that no toxic products are produced; moreover, if the irradiated product is …