Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Our body has a remarkable ability to remember its past encounters with allergens,
pathogens, wounds and irritants, and to react more quickly to the next experience. This …

Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

Epithelial cells that participated in wound repair elicit a more efficient response to future
injuries, which is believed to be locally restricted. Here we show that cell adaptation …

Epithelial tissues line the outer surfaces of the mammalian body and protect from external
harm. In skin, the epithelium is maintained by distinct stem cell populations residing in the …

Epithelial and endothelial cells possess the inherent plasticity to undergo morphological,
cellular, and molecular changes leading to their resemblance of mesenchymal cells. A …

The vertebrate immune system develops in layers, as modes of immunity have evolved on
top of each other through time with the expansion of organismal complexity. The maturation …

Inflammation is an essential host defense mechanism in response to microbial infection and
tissue injury. In addition to its well-established role in infection, inflammation is actively …