Tick immune system: what is known, the interconnections, the gaps, and the challenges

AC Fogaça, G Sousa, DB Pavanelo, E Esteves… - Frontiers in …, 2021 - frontiersin.org
Ticks are ectoparasitic arthropods that necessarily feed on the blood of their vertebrate
hosts. The success of blood acquisition depends on the pharmacological properties of tick …

Proteases in parasitic diseases

JH McKerrow, C Caffrey, B Kelly… - Annu. Rev. Pathol …, 2006 - annualreviews.org
Parasitic diseases represent major global health problems of immense proportion.
Schistosomiasis, malaria, leishmaniasis, Chagas disease, and African sleeping sickness …

Protease inhibitors in tick saliva: the role of serpins and cystatins in tick-host-pathogen interaction

J Chmelař, J Kotál, H Langhansová… - Frontiers in cellular and …, 2017 - frontiersin.org
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of
research of tick protease inhibitors, which represent important constituents of the proteins …

The Drosophila melanogaster Seminal Fluid Protein Acp62F Is a Protease Inhibitor That Is Toxic Upon Ectopic Expression

O Lung, U Tram, CM Finnerty, MA Eipper-Mains… - Genetics, 2002 - academic.oup.com
Drosophila melanogaster seminal fluid proteins stimulate sperm storage and egg laying in
the mated female but also cause a reduction in her life span. We report here that of eight …

An insight into the salivary transcriptome and proteome of the adult female mosquito Culex pipiens quinquefasciatus

JMC Ribeiro, R Charlab, VM Pham, M Garfield… - Insect biochemistry and …, 2004 - Elsevier
To obtain an insight into the salivary transcriptome and proteome (sialome) of the adult
female mosquito Culex quinquefasciatus, a cDNA library was randomly sequenced, and …

Strongylocins, novel antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis

C Li, T Haug, OB Styrvold, TØ Jørgensen… - Developmental & …, 2008 - Elsevier
Sea urchins possess an innate immune system and are regarded as a potential source for
the discovery of new antimicrobial peptides (AMPs). Here we report the purification and …

The use of tick salivary proteins as novel therapeutics

J Chmelař, J Kotál, A Kovaříková… - Frontiers in physiology, 2019 - frontiersin.org
The last three decades of research into tick salivary components have revealed several
proteins with important pharmacological and immunological activities. Two primary interests …

Analysis of the Salivary Gland Transcriptome of Unfed and Partially Fed Amblyomma sculptum Ticks and Descriptive Proteome of the Saliva

E Esteves, SR Maruyama, R Kawahara… - Frontiers in cellular …, 2017 - frontiersin.org
Ticks are obligate blood feeding ectoparasites that transmit a wide variety of pathogenic
microorganisms to their vertebrate hosts. Amblyomma sculptum is vector of Rickettsia …

Ixodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases

AC Fogaça, IC Almeida, MN Eberlin, AS Tanaka… - Peptides, 2006 - Elsevier
The presence of an effective immune response in the hemocoel of arthropods is essential for
survival as it prevents the invasion of pathogens throughout the animal body. Antimicrobial …

A novel protease inhibitor in Bombyx mori is involved in defense against Beauveria bassiana

Y Li, P Zhao, S Liu, Z Dong, J Chen, Z Xiang… - Insect Biochemistry and …, 2012 - Elsevier
Entomopathogenic fungi, such as Beauveria bassiana, penetrate the insect cuticle using a
plethora of hydrolytic enzymes including cuticle-degrading proteases and chitinases, which …