The human brain is characterized by the large size and intricate folding of its cerebral cortex,
which are fundamental for our higher cognitive function and frequently altered in …

The mammalian cerebral cortex is the pinnacle of brain evolution, reaching its maximum
complexity in terms of neuron number, diversity and functional circuitry. The emergence of …

Idiopathic autism spectrum disorder (ASD) is highly heterogeneous, and it remains unclear
how convergent biological processes in affected individuals may give rise to symptoms …

Dimension reduction and (spatial) clustering is usually performed sequentially; however, the
low-dimensional embeddings estimated in the dimension-reduction step may not be …

Cortical neurogenesis follows a simple lineage: apical radial glia cells (RGCs) generate
basal progenitors, and these produce neurons. How this occurs in species with expanded …

Point mutations within the histone H3. 3 are frequent in aggressive childhood brain tumors
known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in …

The major genetic risk factor for Alzheimer's disease (AD), APOE4, accelerates beta-amyloid
(Aβ) plaque formation, but whether this is caused by APOE expressed in microglia or …

Single-cell chromatin accessibility sequencing (scATAC-seq) reconstructs developmental
trajectory by phenotypic similarity. However, inferring the exact developmental trajectory is …

Progenitor cells are critical in preserving organismal homeostasis, yet their diversity and
dynamics in the aged brain remain underexplored. We introduced TrackerSci, a single-cell …

Maternal immune activation (MIA) during critical windows of gestation is correlated with long-
term neurodevelopmental deficits in the offspring, including increased risk for autism …