Spermatogenesis is a complex process in the testis and is a cornerstone of male infertility. The abundance of unsaturated fatty acid and high cell division rate make male germs cells …
SS Pendergraft, H Sadri-Ardekani, A Atala… - Biology of …, 2017 - academic.oup.com
Existing methods for evaluating the potential gonadotoxicity of environmental agents and pharmaceutical compounds rely heavily on animal studies. The current gold standard in vivo …
Although many studies have focused on SARS-CoV-2 infection in the lungs, comparatively little is known about the potential effects of the virus on male fertility. SARS-CoV-2 infection …
M Saitou, H Miyauchi - Cell stem cell, 2016 - cell.com
The germ cell lineage originates early in development and undergoes a series of complex developmental processes that culminate in the generation of fully matured gametes, the …
So far, successful de novo formation of testicular tissue followed by complete spermatogenesis in vitro has been achieved only in rodents. Our findings reveal that primary …
Infertility is a prevalent condition that has insidious impacts on the infertile individuals, their families, and society, which extend far beyond the inability to have a biological child …
T Yokonishi, T Sato, M Komeya, K Katagiri… - Nature …, 2014 - nature.com
With the increasing cure rate of paediatric cancers, infertility, as one of the adverse effects of treatments, has become an important concern for patients and their families. Since semen …
KA Magurany, X Chang, R Clewell… - Toxicological …, 2023 - academic.oup.com
Globally, industries and regulatory authorities are faced with an urgent need to assess the potential adverse effects of chemicals more efficiently by embracing new approach …
KTD Tran, H Valli-Pulaski, A Colvin… - Biology of …, 2022 - academic.oup.com
Medical treatments for cancers or other conditions can lead to permanent infertility. Infertility is an insidious disease that impacts not only the ability to have a biological child but also the …