Application of stem cell therapy for infertility

S Saha, P Roy, C Corbitt, SS Kakar - Cells, 2021 - mdpi.com
Infertility creates an immense impact on the psychosocial wellbeing of affected couples,
leading to poor quality of life. Infertility is now considered to be a global health issue …

[HTML][HTML] Oxidative stress-induced apoptosis and autophagy: Balancing the contrary forces in spermatogenesis

P Sharma, N Kaushal, LR Saleth, S Ghavami… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Spermatogenesis is a complex process in the testis and is a cornerstone of male infertility.
The abundance of unsaturated fatty acid and high cell division rate make male germs cells …

Three-dimensional testicular organoid: a novel tool for the study of human spermatogenesis and gonadotoxicity in vitro

SS Pendergraft, H Sadri-Ardekani, A Atala… - Biology of …, 2017 - academic.oup.com
Existing methods for evaluating the potential gonadotoxicity of environmental agents and
pharmaceutical compounds rely heavily on animal studies. The current gold standard in vivo …

Implications of testicular ACE2 and the renin–angiotensin system for SARS-CoV-2 on testis function

RC Edenfield, CA Easley IV - Nature Reviews Urology, 2022 - nature.com
Although many studies have focused on SARS-CoV-2 infection in the lungs, comparatively
little is known about the potential effects of the virus on male fertility. SARS-CoV-2 infection …

Gametogenesis from pluripotent stem cells

M Saitou, H Miyauchi - Cell stem cell, 2016 - cell.com
The germ cell lineage originates early in development and undergoes a series of complex
developmental processes that culminate in the generation of fully matured gametes, the …

Primary human testicular cells self-organize into organoids with testicular properties

Y Baert, J De Kock, JP Alves-Lopes, O Söder… - Stem Cell Reports, 2017 - cell.com
So far, successful de novo formation of testicular tissue followed by complete
spermatogenesis in vitro has been achieved only in rodents. Our findings reveal that primary …

[HTML][HTML] Experimental methods to preserve male fertility and treat male factor infertility

K Gassei, KE Orwig - Fertility and sterility, 2016 - Elsevier
Infertility is a prevalent condition that has insidious impacts on the infertile individuals, their
families, and society, which extend far beyond the inability to have a biological child …

Offspring production with sperm grown in vitro from cryopreserved testis tissues

T Yokonishi, T Sato, M Komeya, K Katagiri… - Nature …, 2014 - nature.com
With the increasing cure rate of paediatric cancers, infertility, as one of the adverse effects of
treatments, has become an important concern for patients and their families. Since semen …

A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment

KA Magurany, X Chang, R Clewell… - Toxicological …, 2023 - academic.oup.com
Globally, industries and regulatory authorities are faced with an urgent need to assess the
potential adverse effects of chemicals more efficiently by embracing new approach …

Male fertility preservation and restoration strategies for patients undergoing gonadotoxic therapies

KTD Tran, H Valli-Pulaski, A Colvin… - Biology of …, 2022 - academic.oup.com
Medical treatments for cancers or other conditions can lead to permanent infertility. Infertility
is an insidious disease that impacts not only the ability to have a biological child but also the …