Do cryptic reservoirs threaten gambiense-sleeping sickness elimination?

P Büscher, JM Bart, M Boelaert, B Bucheton… - Trends in …, 2018 - cell.com
Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between
1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations …

Transcriptional and Posttranscriptional Regulations of the HLA-G Gene

EC Castelli, LC Veiga-Castelli, L Yaghi… - Journal of …, 2014 - Wiley Online Library
HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-
G coding region has been maintained during the evolution process, in which most of its …

Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity

EC Castelli, J Ramalho, IOP Porto, THA Lima… - Frontiers in …, 2014 - frontiersin.org
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I
genes, located within the major histocompatibility complex (MHC). HLA-G has been the …

HLA‐G: Function, polymorphisms and pathology

A Arnaiz‐Villena, I Juarez… - International Journal …, 2021 - Wiley Online Library
HLA‐G immune modulatory genes and molecules are presently being studied by a
widespread number of research groups. In the present study, we do not aim to be exhaustive …

Worldwide genetic variation at the 3′ untranslated region of the HLA-G gene: balancing selection influencing genetic diversity

A Sabbagh, P Luisi, EC Castelli, L Gineau… - Genes & …, 2014 - nature.com
The HLA-G (human leukocyte antigen-G) molecule plays a pivotal role in immune tolerance
by inhibiting different cell subsets involved in both innate and adaptive immunity. Besides its …

The Role of HLA-G Molecule and HLA-G Gene Polymorphisms in Tumors, Viral Hepatitis, and Parasitic Diseases

FC Dias, EC Castelli, CVA Collares, P Moreau… - Frontiers in …, 2015 - frontiersin.org
Considering that the non-classical HLA-G molecule has well-recognized tolerogenic
properties, HLA-G expression is expected to be deleterious when present in tumor cells and …

Human African trypanosomiasis presenting at least 29 years after infection—what can this teach us about the pathogenesis and control of this neglected tropical …

D Sudarshi, S Lawrence, WO Pickrell… - PLoS neglected …, 2014 - journals.plos.org
The World Health Organization (WHO) has recently announced its plan to eliminate Human
African trypanosomiasis (HAT). The plan's main focus is on the Trypanosoma brucei …

MicroRNAs targeting the immunomodulatory HLA-G gene: a new survey searching for microRNAs with potential to regulate HLA-G

IOP Porto, CT Mendes-Junior, LP Felício, RC Georg… - Molecular …, 2015 - Elsevier
The HLA-G gene is a non-classical class I MHC, responsible for modulating immune
responses by inhibiting Natural Killer and cytotoxic T cells, presenting a crucial role in …

Beyond tsetse–implications for research and control of human African trypanosomiasis epidemics

SC Welburn, DH Molyneux, I Maudlin - Trends in parasitology, 2016 - cell.com
Epidemics of both forms of human African trypanosomiasis (HAT) are confined to spatially
stable foci in Sub-Saharan Africa while tsetse distribution is widespread. Infection rates of …

Tolerance to trypanosomatids: a threat, or a key for disease elimination?

D Berthier, SF Brenière, R Bras-Gonçalves… - Trends in …, 2016 - cell.com
So far, research on trypanosomatid infections has been driven by 'disease by
disease'approaches, leading to different concepts and control strategies. It is, however …