Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

Cancer cells are characterized by a metabolic shift in cellular energy production,
orchestrated by the transcription factor HIF-1α, from mitochondrial oxidative phosphorylation …

The development of hyperpolarized bioresponsive probes for magnetic resonance imaging
(MRI) applications is an emerging and rapidly growing topic in chemistry. A wide range of …

Dysregulation of pH in solid tumors is a hallmark of cancer. In recent years, the role of
altered pH heterogeneity in space, between benign and aggressive tissues, between …

Nuclear hyperpolarization has emerged as a method to dramatically enhance the sensitivity
of NMR spectroscopy. By application of this powerful tool, small molecules with stable …

The extracellular pH (pHe) of solid tumors is often acidic, as a consequence of the Warburg
effect, and an altered metabolic state is often associated with malignancy. It has been shown …

A robust and selective late-stage deuteration methodology was applied to 13C-enriched
amino and alpha hydroxy acids to increase spin–lattice relaxation constant T1 for …

pH is a tightly regulated physiological parameter that is often altered in diseased states like
cancer. The development of biosensors that can be used to non-invasively image pH with …

Hyperpolarization is an emerging method in magnetic resonance imaging that allows
nuclear spin polarization of gases or liquids to be temporarily enhanced by up to five or six …

The contribution of MRS (I) to the in vivo evaluation of cancer‐metabolism‐derived metrics,
mostly since 2016, is reviewed here. Increased carbon consumption by tumour cells, which …