NAD+ Biosynthesis and Signaling in Plants

B Gakière, J Hao, L de Bont, P Pétriacq… - Critical Reviews in …, 2018 - Taylor & Francis
Many metabolic processes that occur in living cells involve oxidation-reduction (redox)
chemistry underpinned by compounds, such as glutathione, ascorbate, and/or pyridine …

The impact of non-enzymatic reactions and enzyme promiscuity on cellular metabolism during (oxidative) stress conditions

G Piedrafita, MA Keller, M Ralser - Biomolecules, 2015 - mdpi.com
Cellular metabolism assembles in a structurally highly conserved, but functionally dynamic
system, known as the metabolic network. This network involves highly active, enzyme …

NAD (P) HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses

NJ Van Bergen, Y Guo, J Rankin, N Paczia… - Brain, 2019 - academic.oup.com
Physical stress, including high temperatures, may damage the central metabolic
nicotinamide nucleotide cofactors [NAD (P) H], generating toxic derivatives [NAD (P) HX] …

B Vitamins: An Update on Their Importance for Plant Homeostasis

TB Fitzpatrick - Annual Review of Plant Biology, 2024 - annualreviews.org
B vitamins are a source of coenzymes for a vast array of enzyme reactions, particularly those
of metabolism. As metabolism is the basis of decisions that drive maintenance, growth, and …

Regulation of lipid rafts, angiogenesis and inflammation by AIBP

L Fang, YI Miller - Current opinion in lipidology, 2019 - journals.lww.com
Regulation of lipid rafts, angiogenesis and inflammation by... : Current Opinion in Lipidology
Regulation of lipid rafts, angiogenesis and inflammation by AIBP : Current Opinion in Lipidology …

Balancing of B6 Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis

M Colinas, M Eisenhut, T Tohge, M Pesquera… - The Plant …, 2016 - academic.oup.com
Vitamin B6 comprises a family of compounds that is essential for all organisms, most notable
among which is the cofactor pyridoxal 5′-phosphate (PLP). Other forms of vitamin B6 …

PYRIDOX(AM)INE 5′-PHOSPHATE OXIDASE3 of Arabidopsis thaliana maintains carbon/nitrogen balance in distinct environmental conditions

P Steensma, M Eisenhut, M Colinas… - Plant …, 2023 - academic.oup.com
The identification of factors that regulate C/N utilization in plants can make a substantial
contribution to optimization of plant health. Here, we explored the contribution of pyridox …

NAXE deficiency: A neurometabolic disorder of NAD (P) HX repair amenable for metabolic correction

J Manor, D Calame, C Gijavanekar, K Fisher… - Molecular genetics and …, 2022 - Elsevier
Abstract The NAD (P) HX repair system is a metabolite damage repair mechanism
responsible for restoration of NADH and NADPH after their inactivation by hydration …

Metabolite damage and metabolite damage control in plants

AD Hanson, CS Henry, O Fiehn… - Annual review of …, 2016 - annualreviews.org
It is increasingly clear that (a) many metabolites undergo spontaneous or enzyme-catalyzed
side reactions in vivo,(b) the damaged metabolites formed by these reactions can be …

NAD (P) HX repair deficiency causes central metabolic perturbations in yeast and human cells

J Becker‐Kettern, N Paczia, JF Conrotte… - The FEBS …, 2018 - Wiley Online Library
NADHX and NADPHX are hydrated and redox inactive forms of the NADH and NADPH
cofactors, known to inhibit several dehydrogenases in vitro. A metabolite repair system that …