Emerging evidence indicates that impaired cellular energy metabolism is the defining
characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal …

Mitochondria are dynamic organelles whose functional integrity requires a coordinated
supply of proteins and phospholipids. Defined functions of specific phospholipids, like the …

Phospholipids play multiple roles in cells by establishing the permeability barrier for cells
and cell organelles, by providing the matrix for the assembly and function of a wide variety of …

Since it has been recognized that mitochondria are crucial not only for energy metabolism
but also for other cellular functions, there has been a growing interest in cardiolipin, the …

Cardiolipin is a unique phospholipid with dimeric structure, carrying four acyl groups and
two negative charges. It is exclusively found in bacterial and mitochondrial membranes …

The aim of this study was to investigate the influence of reactive oxygen species (ROS) on
the activity of complex I and on the cardiolipin content in bovine heart submitochondrial …

Abstract F 1 F 0 ATP synthase forms dimers that tend to assemble into large supramolecular
structures. We show that the presence of cardiolipin is critical for the degree of …

An isolated defect of respiratory chain complex I activity is a frequent biochemical
abnormality in mitochondrial disorders. Despite intensive investigation in recent years, in …

Mitochondria are known as the powerhouse of eukaryotic cells. Energy production occurs in
specific dynamic membrane invaginations in the inner mitochondrial membrane called …

A basic feature of eukaryotic cells is that they contain a nucleus and numerous distinctive
membrane-bounded organelles within the cytoplasm. Prominent among these intracellular …