Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …

The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

Despite lack of tumor control in many models, spontaneous T cell priming occurs frequently
in response to a growing tumor. However, the innate immune mechanisms that promote …

Purpose To update the recommendations for the use of tumor marker tests in the prevention,
screening, treatment, and surveillance of breast cancer. Methods For the 2007 update, an …

Better biomarkers are urgently needed to improve diagnosis, guide molecularly targeted
therapy and monitor activity and therapeutic response across a wide spectrum of disease …

Numerous innate and adaptive immune effector cells and molecules participate in the
recognition and destruction of cancer cells, a process that is known as cancer …

Cancer is a leading cause of death in the world. Increasing evidence has demonstrated that
early diagnosis holds the key towards effective treatment outcome. Cancer biomarkers are …

A link between autoimmune responses and cancer via autoantibodies was first described in
the 1950s. Since, autoantibodies have been studied for their potential use as cancer …

Genomic technologies offer the promise of a comprehensive understanding of cancer.
These technologies are being used to characterize tumours at the molecular level, and …

The introduction of technologies such as mass spectrometry and protein and DNA arrays,
combined with our understanding of the human genome, has enabled simultaneous …