Telomeres at the termini of human chromosomes are shortened with each round of cell
division due to the “end replication problem” as well as oxidative stress. During …

Background Glucocorticoid‐induced osteoporosis is the most common secondary cause of
osteoporosis, which increases the risk of fracture. Long non‐coding RNA telomerase RNA …

Background Bladder cancer (BC) is the 10th most frequent tumor worldwide. Evidence
shows an association between elevated risk of BC and various single nucleotide …

A delicate balance of BMP activity is critical for tissue formation and organogenesis.
However, the mechanical molecular details in ensuring the proper duration and intensity of …

Genome-wide association studies (GWAS) identified a coding single nucleotide
polymorphism, MYNN rs10936599, at chromosome 3q. MYNN gene encodes myoneurin …

Purpose Intervertebral disc degeneration (IVDD) considerably impacts global disability and
quality of life. Although potential links between plasma proteins and IVDD exist, their causal …

Pituitary adenoma (PA) is the most common benign tumor of the pituitary gland. The
pathogenesis of most PA is considered as a multifactorial process, that involves genetic …

Variants in a gene cluster upstream-adjacent to TERC on human chromosome 3, which
includes genes APRM, LRRC31, LRRC34 and MYNN, have been associated with telomere …

Typically, electronic health record data are not collected towards a specific research
question. Instead, they comprise numerous observations recruited at different ages, whose …

Telomere shortening is usually considered a biomarker of ageing. Harmful alcohol use
promotes accelerated biological ageing and alcohol use disorders (AUDs) are associated …