Enzymes, receptors, and other binding molecules in biological processes can recognize
enantiomers as different molecular entities, due to their different dissociation constants …

Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …

Abstract Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by
mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the …

Organic cation transporters (OCTs) 1, 2, and 3 facilitate cellular uptake of structurally diverse
endogenous and exogenous substances. However, their substrate and inhibitor specificity …

OCT1 is the most highly expressed cation transporter in the liver and affects
pharmacokinetics and pharmacodynamics. Newly marketed drugs have previously been …

Drought stress is a major constraint on plant growth and agricultural productivity. Caffeic
acid O-methyltransferase (COMT), an enzyme involved in the methylation of various …

The organic cation transporter 1 (OCT1, SLC22A1) transports a large number of structurally
diverse endogenous and exogenous substrates. There are numerous known competitive …

Stereoselectivity is important in many pharmacological processes but its impact on drug
membrane transport is scarcely understood. Recent studies showed strong stereoselective …

The mechanisms of stereoselectivity of the interaction of chiral drugs with active sites of
enzymes and cell receptors attract significant attention. The first reason is the difference in …

Psychostimulants are used therapeutically and for illegal recreational purposes. Many of
these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters …