Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

Plasmodium vivax continues to cause significant morbidity outside Africa with more than
50% of malaria cases in many parts of South and South-east Asia, Pacific islands, Central …

Malaria transmission-blocking vaccines (TBVs) target the development of Plasmodium
parasites within the mosquito, with the aim of preventing malaria transmission from one …

Malaria elimination means cessation of parasite transmission. At present, the declining
malaria incidence in many countries has made elimination a feasible goal. Transmission …

The continued global burden of malaria can in part be attributed to a complex lifecycle, with
both human hosts and mosquito vectors serving as transmission reservoirs. In preclinical …

M1 aminopeptidase enzymes are a diverse family of metalloenzymes characterized by
conserved structure and reaction specificity. Excluding viruses, M1 aminopeptidases are …

Despite decades of effort battling against malaria, the disease is still a major cause of
morbidity and mortality. Transmission-blocking vaccines (TBVs) that target sexual stage …

Control measures have significantly reduced malaria morbidity and mortality in the last two
decades; however, the downward trends have stalled and have become complicated by the …

Eukaryotic parasites and pathogens continue to cause some of the most detrimental and
difficult to treat diseases (or disease states) in both humans and animals, while also …

Recent reviews (Feachem et al.; Alonso et al.) have concluded that in order to have a
sustainable impact on the global burden of malaria, it is essential that we knowingly reduce …