The use of Drosophila melanogaster for studies of toxicology has grown considerably in the
last decade. The Drosophila model has long been appreciated as a versatile and powerful …

Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …

Neural stem cells (NSCs) of the ventricular-subventricular zone (V-SVZ) generate numerous
cell types. The uncoupling of mRNA transcript availability and translation occurs during the …

The development of single-cell and single-nucleus transcriptome technologies is enabling
the unraveling of the molecular and cellular heterogeneity of psychiatric disorders. The …

Drug addiction and the circuitry for learning and memory are intimately intertwined. Drugs of
abuse create strong, inappropriate, and lasting memories that contribute to many of their …

The brain constantly compares past and present experiences to predict the future, thereby
enabling instantaneous and future behavioral adjustments. Integration of external …

Fetal alcohol exposure can lead to developmental abnormalities, intellectual disability, and
behavioral changes, collectively termed fetal alcohol spectrum disorder (FASD). In 2015, the …

The addictive properties of psychostimulants such as cocaine, amphetamine,
methamphetamine, and methylphenidate are based on their ability to increase …

We used Drosophila melanogaster to map the genetic basis of naturally occurring variation
in voluntary consumption of cocaine and methamphetamine. We derived an outbred …

Cocaine (COC) and its main metabolite, the benzoylecgonine (BE), are the main illicit drugs
measured in aquatic system worldwide, with concentrations up to hundreds of ng/L …