The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

In the last decade, clear evidence has emerged that the cellular components of skeletal
muscle are important sites for the release of proteins and peptides called “myokines” …

Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle
performance, maintaining metabolic function and supporting longevity and healthspan …

Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and
function. Given the worldwide aging demographics, this is a major contributor to morbidity …

Skeletal muscle tissue demonstrates global hypermethylation with age. However,
methylome changes across the time-course of differentiation in aged human muscle derived …

Systemic deletion of senescent cells leads to robust improvements in cognitive,
cardiovascular, and whole‐body metabolism, but their role in tissue reparative processes is …

Aging is characterized by a progressive decline of physiological integrity leading to the loss
of tissue function and vulnerability to disease, but its causes remain poorly understood …

Advanced in vitro models of human skeletal muscle tissue are increasingly needed to model
complex developmental dynamics and disease mechanisms not recapitulated in animal …

Skeletal muscle has a remarkable capacity to regenerate by virtue of its resident stem cells
(satellite cells). This capacity declines with aging, although whether this is due to extrinsic …

Skeletal muscle mass and function decline with aging, a process known as sarcopenia,
which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is …