Regulatory pathways and drugs associated with ferroptosis in tumors

D Wang, L Tang, Y Zhang, G Ge, X Jiang, Y Mo… - Cell Death & …, 2022 - nature.com
Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS).
The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane …

The main molecular mechanisms underlying methamphetamine-induced neurotoxicity and implications for pharmacological treatment

X Yang, Y Wang, Q Li, Y Zhong, L Chen… - Frontiers in molecular …, 2018 - frontiersin.org
Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated
neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the …

Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress-and mitochondrial stress-dependent pathways

S Jia, X Xu, S Zhou, Y Chen, G Ding, L Cao - Cell death & disease, 2019 - nature.com
Pancreatic cancer is one of the most aggressive tumors and patients have poor survival
rates. Fisetin, a natural flavonoid, was recently reported to have antitumor effects in various …

NUPR1: a critical regulator of the antioxidant system

C Huang, P Santofimia-Castaño, J Iovanna - Cancers, 2021 - mdpi.com
Simple Summary Nuclear protein 1 (NUPR1) is activated in cellular stress and is expressed
at high levels in cancer cells. Much evidence has been gathered supporting its critical role in …

The role of non-coding RNAs in methamphetamine-induced neurotoxicity

L Xu, L Li, Q Chen, Y Huang, X Chen… - Cellular and Molecular …, 2023 - Springer
Methamphetamine (METH) is an amphetamine-type stimulant that is highly toxic to the
central nervous system (CNS). Repeated intake of METH can lead to addiction, which has …

The role of NUPR1 in response to stress and cancer development

S Liu, M Costa - Toxicology and Applied Pharmacology, 2022 - Elsevier
Stress contributes to the development of many human diseases, including cancer. Based on
the source of stress, it can be divided into external stress, such as environmental …

Toll-like receptor 4 mediates methamphetamine-induced neuroinflammation through caspase-11 signaling pathway in astrocytes

SH Du, DF Qiao, CX Chen, S Chen, C Liu… - Frontiers in molecular …, 2017 - frontiersin.org
Methamphetamine (METH) is an amphetamine-typed stimulant drug that is increasingly
being abused worldwide. Previous studies have shown that METH toxicity is systemic …

The significance of NLRP inflammasome in neuropsychiatric disorders

Y Shen, L Qian, H Luo, X Li, Y Ruan, R Fan, Z Si… - Brain Sciences, 2022 - mdpi.com
The NLRP inflammasome is a multi-protein complex which mainly consists of the nucleotide-
binding oligomerization domain, leucine-rich repeat, and pyrin domain. Its activation is …

NUPR1 and its potential role in cancer and pathological conditions

TA Martin, AX Li, AJ Sanders, L Ye… - International …, 2021 - spandidos-publications.com
Abstract Nuclear protein‑1 (NUPR1) is also known as Com‑1 or p8. It is a protein primarily
found in the nucleus of various cells, including cancer cells, and it has been found to play an …

Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats

XH Tan, KK Zhang, JT Xu, D Qu, LJ Chen, JH Li… - Food and Chemical …, 2020 - Elsevier
Methamphetamine (METH) is a highly addictive stimulant that results in serious and
persistent neurotoxic effects. Studies have indicated that luteolin, a flavonoid, may confer …