The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

Background: Recent studies have shown that hematopoietic stem cells can undergo clonal
expansion secondary to somatic mutations in leukemia-related genes, thus leading to an …

The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to
further injury that contributes to the final infarct size. Locally released danger-associated …

Nonalcoholic fatty liver disease (NAFLD) is a common, progressive liver disease that affects
up to one-quarter of the adult population worldwide. The clinical and economic burden of …

Cardiac arrhythmias and the resulting sudden cardiac death are significant cardiovascular
complications that continue to impose a heavy burden on patients and society. An emerging …

Chronic low-grade inflammation contributes to the development of several diseases,
including cardiovascular disease. Adequate strategies to target inflammation in …