The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

T cells are essential immune cells responsible for identifying and eliminating pathogens.
Through interactions between their T-cell antigen receptors (TCRs) and antigens presented …

Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

T cells use finger-like protrusions called 'microvilli'to interrogate their targets, but why they do
so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer …

The B cell antigen receptor (BCR) is composed of a membrane-bound class M, D, G, E or A
immunoglobulin for antigen recognition,–and a disulfide-linked Igα (also known as CD79A) …

Immunoglobulin E (IgE) plays a pivotal role in allergic responses,. The high-affinity IgE
receptor, FcεRI, found on mast cells and basophils, is central to the effector functions of IgE …

A common event upon receptor–ligand engagement is the formation of receptor clusters on
the cell surface, in which signaling molecules are specifically recruited or excluded to form …

Abstract BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …

Mechanical force has repeatedly been highlighted to be involved in T cell activation.
However, the biological significance of mechanical force for T cell receptor signaling …

Simple Summary CD3 complex provides the first signal sensed by the TCR of the
lymphocyte to trigger its activation. Thus, it becomes a very attractive receptor to determine …