[HTML][HTML] The road to precision medicine: Eliminating the “One Size Fits All” approach in Alzheimer's disease

T Behl, I Kaur, A Sehgal, S Singh, A Albarrati… - Biomedicine & …, 2022 - Elsevier
The expeditious advancement of Alzheimer's Disease (AD) is a threat to the global
healthcare system, that is further supplemented by therapeutic failure. The prevalence of this …

Alzheimer's disease-related epigenetic changes: novel therapeutic targets

A Paniri, MM Hosseini, H Akhavan-Niaki - Molecular Neurobiology, 2024 - Springer
Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

Stability of proteins in dried blood spot biobanks

J Björkesten, S Enroth, Q Shen, L Wik… - Molecular & Cellular …, 2017 - ASBMB
An important motivation for the construction of biobanks is to discover biomarkers that
identify diseases at early, potentially curable stages. This will require biobanks from large …

Tau oligomers in cerebrospinal fluid in Alzheimer's disease

U Sengupta, E Portelius, O Hansson… - Annals of clinical …, 2017 - Wiley Online Library
Objective With an increasing incidence of Alzheimer's disease (AD) and neurodegenerative
tauopathies, there is an urgent need to develop reliable biomarkers for the diagnosis and …

[HTML][HTML] The emerging role of PET imaging in dementia

L Iaccarino, A Sala, SP Caminiti, D Perani - F1000Research, 2017 - ncbi.nlm.nih.gov
A compelling need in the field of neurodegenerative diseases is the development and
validation of biomarkers for early identification and differential diagnosis. The availability of …

A systematic review of neuroimaging studies comparing individuals with subjective cognitive decline to healthy controls

AF Parker, L Ohlhauser, V Scarapicchia… - Journal of …, 2022 - content.iospress.com
Background: Individuals with subjective cognitive decline (SCD) are hypothesized to be the
earliest along the cognitive continuum between healthy aging and Alzheimer's disease (AD) …

Early detection of Alzheimer's disease using neuropsychological tests: a predict–diagnose approach using neural networks

D Mukherji, M Mukherji, N Mukherji… - Brain Informatics, 2022 - Springer
Alzheimer's disease (AD) is a slowly progressing disease for which there is no known
therapeutic cure at present. Ongoing research around the world is actively engaged in the …

Recent trends in active and passive immunotherapies of Alzheimer's disease

M Alshamrani - Antibodies, 2023 - mdpi.com
In the elderly, a debilitating condition known as dementia, which is a major health concern,
is caused by Alzheimer's disease (AD). Despite promising advances by researchers, there is …

Comparison of olfactory and gustatory disorders in Alzheimer's disease

M Kouzuki, T Suzuki, M Nagano, S Nakamura… - Neurological …, 2018 - Springer
Patients with Alzheimer's disease (AD) develop olfactory and gustatory disorders. However,
the order of failure and relevance of the pathophysiology are unclear. We compared …

A blood-based signature of cerebrospinal fluid Aβ1–42 status

B Goudey, BJ Fung, C Schieber, NG Faux - Scientific reports, 2019 - nature.com
It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present
and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early …