Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Mechanistic understanding of lanthipeptide biosynthetic enzymes

LM Repka, JR Chekan, SK Nair… - Chemical …, 2017 - ACS Publications
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides
(RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic …

New insights into the biosynthetic logic of ribosomally synthesized and post-translationally modified peptide natural products

MA Ortega, WA Van Der Donk - Cell chemical biology, 2016 - cell.com
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large
group of structurally diverse natural products. Their biological activities and unique …

The expanding structural variety among bacteriocins from Gram-positive bacteria

JZ Acedo, S Chiorean, JC Vederas… - FEMS microbiology …, 2018 - academic.oup.com
Bacteria use various strategies to compete in an ecological niche, including the production
of bacteriocins. Bacteriocins are ribosomally synthesized antibacterial peptides, and it has …

YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function

BJ Burkhart, CJ Schwalen, G Mann, JH Naismith… - Chemical …, 2017 - ACS Publications
With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …

Macrocyclization and backbone modification in RiPP biosynthesis

H Lee, WA Van Der Donk - Annual review of biochemistry, 2022 - annualreviews.org
The past decade has seen impressive advances in understanding the biosynthesis of
ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most …

Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes

H Onaka - The Journal of Antibiotics, 2017 - nature.com
Streptomyces have the potential to produce more than 30 secondary metabolites; however,
the expression of most metabolite biosynthetic gene clusters is cryptic or silent. Indeed, the …

Utilizing cross-species co-cultures for discovery of novel natural products

L Zhuang, H Zhang - Current Opinion in Biotechnology, 2021 - Elsevier
Highlights•Cross-species co-cultures can be used to activate cryptic genes' expression for
biosynthesis of novel natural products.•A variety of co-cultivation methods have been …

A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor

PN Daniels, H Lee, RA Splain, CP Ting, L Zhu… - Nature …, 2022 - nature.com
Aromatic amines in nature are typically installed with Glu or Gln as the nitrogen donor. Here
we report a pathway that features glycyl-tRNA instead. During the biosynthesis of …