Mass spectrometry-based proteomics as an emerging tool in clinical laboratories

AG Birhanu - Clinical Proteomics, 2023 - Springer
Mass spectrometry (MS)-based proteomics have been increasingly implemented in various
disciplines of laboratory medicine to identify and quantify biomolecules in a variety of …

Biomarker discovery in mass spectrometry‐based urinary proteomics

S Thomas, L Hao, WA Ricke, L Li - PROTEOMICS–Clinical …, 2016 - Wiley Online Library
Urinary proteomics has become one of the most attractive topics in disease biomarker
discovery. MS‐based proteomic analysis has advanced continuously and emerged as a …

Comparison of Information-Dependent Acquisition, SWATH, and MSAll Techniques in Metabolite Identification Study Employing Ultrahigh-Performance Liquid …

X Zhu, Y Chen, R Subramanian - Analytical chemistry, 2014 - ACS Publications
Sensitive and selective liquid chromatography–mass spectrometry (LC–MS) analysis is a
powerful and essential tool for metabolite identification in drug discovery and development …

Recent developments in clinical plasma proteomics—applied to cardiovascular research

NB Palstrøm, R Matthiesen, LM Rasmussen, HC Beck - Biomedicines, 2022 - mdpi.com
The human plasma proteome mirrors the physiological state of the cardiovascular system, a
fact that has been used to analyze plasma biomarkers in routine analysis for the diagnosis …

Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells

EW Newell, MM Davis - Nature biotechnology, 2014 - nature.com
Adaptive immune responses often begin with the formation of a molecular complex between
a T-cell receptor (TCR) and a peptide antigen bound to a major histocompatibility complex …

Nanopore: Emerging for detecting protein post-translational modifications

X Zhao, H Qin, M Tang, X Zhang, G Qing - TrAC Trends in Analytical …, 2024 - Elsevier
Protein post-translational modifications (PTMs) play pivotal roles in almost every cellular
process, influencing protein stability, localization, interactions, and enzymatic activities. PTM …

From single level analysis to multi-omics integrative approaches: a powerful strategy towards the precision oncology

MEG Cantafio, K Grillone, D Caracciolo… - The Road from …, 2019 - taylorfrancis.com
This chapter discusses general concepts on the generation of omics data, along with
available strategies for multi-omics data analysis and integration in the context of clinical …

Potential predictive plasma biomarkers for cervical cancer by 2D-DIGE proteomics and Ingenuity Pathway Analysis

X Guo, Y Hao, M Kamilijiang, A Hasimu, J Yuan, G Wu… - Tumor Biology, 2015 - Springer
The current methods available for screening and detecting cervical squamous cell
carcinoma (CSCC) have insufficient sensitivity and specificity. As a result, many patients …

Clinical proteomics for prostate cancer: understanding prostate cancer pathology and protein biomarkers for improved disease management

C Tonry, S Finn, J Armstrong, SR Pennington - Clinical Proteomics, 2020 - Springer
Following the introduction of routine Prostate Specific Antigen (PSA) screening in the early
1990′ s, Prostate Cancer (PCa) is often detected at an early stage. There are also a …

Mass spectrometry‐based proteomic approaches for salivary protein biomarkers discovery and dental caries diagnosis: A critical review

P Ahmad, A Hussain… - Mass Spectrometry …, 2024 - Wiley Online Library
Dental caries is a multifactorial chronic disease resulting from the intricate interplay among
acid‐generating bacteria, fermentable carbohydrates, and several host factors such as …