Priming central sound processing circuits through induction of spontaneous activity in the cochlea before hearing onset
CJ Kersbergen, DE Bergles - Trends in neurosciences, 2024 - cell.com
Sensory systems experience a period of intrinsically generated neural activity before
maturation is complete and sensory transduction occurs. Here we review evidence …
maturation is complete and sensory transduction occurs. Here we review evidence …
Damage-evoked signals in cochlear neurons and supporting cells
MB Wood, N Nowak, PA Fuchs - Frontiers in Neurology, 2024 - frontiersin.org
In addition to hearing loss, damage to the cochlea can lead to gain of function pathologies
such as hyperacusis. It has been proposed that painful hyperacusis, noxacusis, may be …
such as hyperacusis. It has been proposed that painful hyperacusis, noxacusis, may be …
Absence of oncomodulin increases susceptibility to noise-induced outer hair cell death and alters mitochondrial morphology
KE Murtha, WD Sese, K Sleiman, J Halpage… - Frontiers in …, 2024 - frontiersin.org
Cochlear outer hair cells (OHCs) play a fundamental role in the hearing sensitivity and
frequency selectivity of mammalian hearing and are especially vulnerable to noise-induced …
frequency selectivity of mammalian hearing and are especially vulnerable to noise-induced …
Calcium-Associated Proteins in Neuroregeneration
The dysregulation of intracellular calcium levels is a critical factor in neurodegeneration,
leading to the aberrant activation of calcium-dependent processes and, ultimately, cell …
leading to the aberrant activation of calcium-dependent processes and, ultimately, cell …
[HTML][HTML] Two new mouse alleles of Ocm and Slc26a5
M Lachgar-Ruiz, NJ Ingham, E Martelletti, J Chen… - Hearing Research, 2024 - Elsevier
The genes Ocm (encoding oncomodulin) and Slc26a5 (encoding prestin) are expressed
strongly in outer hair cells and both are involved in deafness in mice. However, it is not clear …
strongly in outer hair cells and both are involved in deafness in mice. However, it is not clear …
Lack of Oncomodulin Increases ATP-Dependent Calcium Signaling and Susceptibility to Noise in Adult Mice
Tight regulation of Ca2+ is crucial for the function of cochlear outer hair cells (OHCs).
Dysregulation of Ca2+ homeostasis in OHCs is associated with impaired hearing function …
Dysregulation of Ca2+ homeostasis in OHCs is associated with impaired hearing function …
[PDF][PDF] Calcium-Associated Proteins in Neuroregeneration. Biomolecules 2024, 14, 183
The dysregulation of intracellular calcium levels is a critical factor in neurodegeneration,
leading to the aberrant activation of calcium-dependent processes and, ultimately, cell …
leading to the aberrant activation of calcium-dependent processes and, ultimately, cell …
Early Sensory Deficits in Alzheimer's Disease: A Review of Potential Integrating Diagnostic Methods
Y Yang - Journal of Clinical and Translational Science - cambridge.org
Alzheimer's Disease (AD) is the most common cause of dementia globally, leading to
memory loss and cognitive decline. Accumulating studies have uncovered the correlation …
memory loss and cognitive decline. Accumulating studies have uncovered the correlation …