Size-controlled growth of CdSe nanocrystals in microfluidic reactors

EM Chan, RA Mathies, AP Alivisatos - Nano Letters, 2003 - ACS Publications
Cadmium selenide nanocrystals are reproducibly synthesized at high-temperature in
continuous flow, chip-based microfluidic reactors and exhibit size distributions comparable …

Integrated portable genetic analysis microsystem for pathogen/infectious disease detection

ET Lagally, JR Scherer, RG Blazej, NM Toriello… - Analytical …, 2004 - ACS Publications
An integrated portable genetic analysis microsystem including PCR amplification and
capillary electrophoretic (CE) analysis coupled with a compact instrument for electrical …

Microfabricated 384-lane capillary array electrophoresis bioanalyzer for ultrahigh-throughput genetic analysis

CA Emrich, H Tian, IL Medintz, RA Mathies - Analytical Chemistry, 2002 - ACS Publications
A microfabricated 384-lane capillary array electrophoresis device is developed and utilized
for massively parallel genetic analysis. The 384 capillary lanes, arrayed radially about the …

Advances in polymerase chain reaction on microfluidic chips

MG Roper, CJ Easley, JP Landers - Analytical chemistry, 2005 - ACS Publications
BACKGROUND Genome Era. The mapping and sequencing of the human genome
represents a monumental accomplishment that will impact medicine and biology in ways …

Real-time nucleic acid sequence-based amplification in nanoliter volumes

A Gulliksen, L Solli, F Karlsen, H Rogne… - Analytical …, 2004 - ACS Publications
Real-time nucleic acid sequence-based amplification (NASBA) is an isothermal method
specifically designed for amplification of RNA. Fluorescent molecular beacon probes enable …

Multichannel PCR-CE microdevice for genetic analysis

CN Liu, NM Toriello, RA Mathies - Analytical chemistry, 2006 - ACS Publications
We have developed a fully integrated multichannel polymerase chain reaction-capillary
electrophoresis (PCR-CE) microdevice with nanoliter reactor volumes for highly parallel …

Integrated microfluidic device for solid-phase extraction coupled to micellar electrokinetic chromatography separation

JD Ramsey, GE Collins - Analytical chemistry, 2005 - ACS Publications
An integrated microdevice was utilized for the autonomous coupling of solid-phase
extraction (SPE) to micellar electrokinetic chromatography (MEKC). Porous plugs of …

Ligase detection reaction/hybridization assays using three-dimensional microfluidic networks for the detection of low-abundant DNA point mutations

M Hashimoto, ML Hupert, MC Murphy… - Analytical …, 2005 - ACS Publications
We have fabricated a flow-through biochip assembly that consisted of two different
microchips:(1) a polycarbonate (PC) chip for performing an allele-specific ligation detection …

Microfluidic serial dilution circuit

BM Paegel, WH Grover, AM Skelley… - Analytical …, 2006 - ACS Publications
In vitro evolution of RNA molecules requires a method for executing many consecutive serial
dilutions. To solve this problem, a microfluidic circuit has been fabricated in a three-layer …

Capillary electrophoresis chips with a sheath-flow supported electrochemical detection system

P Ertl, CA Emrich, P Singhal, RA Mathies - Analytical Chemistry, 2004 - ACS Publications
Microfabricated capillary electrophoresis chips containing an integrated sheath-flow
electrochemical detector are developed with the goal of minimizing the influence of …