Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …

Segmentation is a fundamental feature of the vertebrate body plan. This metameric
organization is first implemented by somitogenesis in the early embryo, when paired …

Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Studies of cultured embryos have provided insights into human peri-implantation
development. However, detailed knowledge of peri-implantation lineage development as …

Integrated in vitro models of human organogenesis are needed to elucidate the multi-
systemic events underlying development and disease. Here we report the generation of …

Aggregates of stem cells can break symmetry and self-organize into embryo-like structures
with complex morphologies and gene expression patterns. Mechanisms including reaction …

Gastruloids are a powerful in vitro model of early human development. However, although
elongated and composed of all three germ layers, human gastruloids do not morphologically …

Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …

Our ability to study early human post-implantation development remains highly limited due
to the ethical and technical challenges associated with intrauterine development of the …