α-Synuclein in synaptic function and dysfunction
Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …
physiological conditions, it binds to synaptic vesicle membranes and functions in …
Impaired dopamine release in Parkinson's disease
Parkinson's disease is the second most common neurodegenerative disease and yet the
early pathophysiological events of the condition and sequences of dysfunction remain …
early pathophysiological events of the condition and sequences of dysfunction remain …
The physiological role of α‐synuclein and its relationship to Parkinson's Disease
D Sulzer, RH Edwards - Journal of neurochemistry, 2019 - Wiley Online Library
The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …
In this review, we discuss recent results concerning its primary function, which appears to be …
Alpha-synuclein aggregation in Parkinson's disease
E Srinivasan, G Chandrasekhar… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …
Initiation and propagation of α-synuclein aggregation in the nervous system
BA Hijaz, LA Volpicelli-Daley - Molecular neurodegeneration, 2020 - Springer
The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …
Mechanisms of α-synuclein induced synaptopathy in Parkinson's disease
JC Bridi, F Hirth - Frontiers in neuroscience, 2018 - frontiersin.org
Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …
Synaptic, mitochondrial, and lysosomal dysfunction in Parkinson's disease
The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …
Review of the current state of protein aggregation inhibition from a materials chemistry perspective: Special focus on polymeric materials
Protein instability caused by exposure to external additives or severe stress may result in
different diseases. Of these diseases, many are triggered by protein misfolding and …
different diseases. Of these diseases, many are triggered by protein misfolding and …
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity
In Parkinson's disease and other synucleinopathies, the elevation of α-synuclein
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …
Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models
E Taoufik, G Kouroupi, O Zygogianni… - Open …, 2018 - royalsocietypublishing.org
Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …
synapse structure and function, and can be either the cause or the consequence in specific …