Fundamental cause theory (FCT) was originally proposed to explain how socioeconomic
inequalities in health emerged and persisted over time. The concept was that higher …

Although advances in care have spurred improvements in cardiovascular outcomes,
cardiovascular disease remains the leading cause of death in the United States and around …

Importance US life expectancy has not kept pace with that of other wealthy countries and is
now decreasing. Objective To examine vital statistics and review the history of changes in …

The accepted wisdom about the US overdose crisis singles out prescribing as the causative
vector. Although drug supply is a key factor, we posit that the crisis is fundamentally fueled …

Importance Although female representation has increased in clinical trials, little is known
about how clinical trial representation compares with burden of disease or is associated with …

INTRODUCTION The epidemic of substance use disorders and drug overdose deaths is a
growing public health crisis in the United States. Every day, 174 people die from drug …

Background Brentuximab vedotin is an anti-CD30 antibody–drug conjugate that has been
approved for relapsed and refractory Hodgkin's lymphoma. Methods We conducted an open …

Objectives. To examine 47 years of US urban and rural mortality trends at the county level,
controlling for effects of education, income, poverty, and race. Methods. We obtained (1) …

Determining long-term trends in chronic pain prevalence is critical for evaluating and
shaping US health policies, but little research has examined such trends. This study (1) …

A new cardiometabolic-based chronic disease (CMBCD) model is presented that provides a
basis for early and sustainable, evidence-based therapeutic targeting to promote …