Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …

Altered metabolism and deregulated cellular energetics are now considered a hallmark of
all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor …

Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for
biomarker discovery and personalized medicine and has great potential to elucidate the …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

Galectins are a family of widely expressed β-galactoside-binding lectins in metazoans. The
15 mammalian galectins have either one or two conserved carbohydrate recognition …

Simple Summary O-linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational
modification (PTM) linking nutrient flux through the hexosamine biosynthetic pathway (HBP) …

Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are
currently considered the most significant and prevalent metabolic changes observed in …

The immune system is highly controlled and fine-tuned by glycosylation, through the
addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell …

The glycocalyx coating the outside of most cells is a polymer meshwork comprising proteins
and complex sugar chains called glycans. From a physical perspective, the glycocalyx has …

The de novo synthesis of fatty acids has emerged as a therapeutic target for various
diseases, including cancer. Because cancer cells are intrinsically buffered to combat …