Anthracyclines are among the most effective anticancer drugs ever developed.
Unfortunately, their clinical use is severely limited by the development of a progressive dose …

Anthracyclines remain the cornerstone in the treatment of many malignancies including
lymphomas, leukaemias, and sarcomas. Unfortunately, the clinical use of these potent …

Mitochondria play central roles in cell life as a source of energy and in cell death by inducing
apoptosis. Many important functions of mitochondria change in cancer, and these organelles …

We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer
platinum drugs when the drugs are combined with (or loaded into) one of the two most …

Chemotherapies often induce drug-resistance in cancer cells and simultaneously stimulate
proliferation and activation of Myeloid-Derived Suppressor Cells (MDSCs) to inhibit anti …

The kinetics of the glucose oxidase-catalyzed reaction of glucose with O 2, which produces
gluconic acid and hydrogen peroxide, and the catalase-assisted breakdown of hydrogen …

We studied the effect of two types of mesoporous silica nanoparticles, MCM-41 and SBA-15,
on mitochondrial O2 consumption (respiration) in HL-60 (myeloid) cells, Jurkat (lymphoid) …

OBJECTIVE: To investigate the effects of the psychotropic compounds Δ9-
tetrahydrocannabinol (Δ9-THC) and Δ8-tetrahydrocannabinol (Δ8-THC) on sperm …

Mitochondria are the cell powerhouses but also contain the mechanisms leading to cell
death. Many signals converge on mitochondria to cause the permeabilization of …

Abstract Background and Purpose: The primary cannabinoids, Δ9-tetrahydrocannabinol (Δ9-
THC) and Δ8-tetrahydrocannabinol (Δ8-THC) are known to disturb the mitochondrial …