Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …

In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

Alzheimer's disease (AD) is associated with memory impairment and altered peripheral
metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery …

Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …

The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway
constitute the fulcrum in many vital cellular processes, including cell growth, differentiation …

A growing body of evidence supports a role for glial-produced neuroimmune factors,
including the cytokine IL-6, in CNS physiology and pathology. CNS expression of IL-6 has …

This review describes the role of cytokines and their downstream signaling cascades on the
modulation of learning and memory. Immune proteins are required for many key neural …

Atherosclerosis is the main pathological basis of ischemic cardiovascular and
cerebrovascular diseases and has attracted more attention in recent years. Multiple studies …

JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of
gene expression. Primarily identified as functioning in hematopoietic cells, its role has been …