Malaria has been the pre-eminent cause of early mortality in many parts of the world
throughout much of the last five thousand years and, as a result, it is the strongest force for …

Two subclasses of quinoline antimalarial drugs are used clinically. Both act on the
endolysosomal system of malaria parasites, but in different ways. Treatment with 4 …

Malaria causes approximately one million fatalities per year, mostly among African children.
Although highlighted by the strong protective effect of the sickle-cell trait,, the full impact of …

Background Human genetic factors are important determinants of malaria risk. We
investigated associations between multiple candidate polymorphisms—many related to the …

Together with micronemes and rhoptries, dense granules are specialised secretory
organelles of Apicomplexa parasites. Among Apicomplexa, Plasmodium represents a model …

Calcium-dependent protein kinases play a crucial role in intracellular calcium signaling in
plants, some algae and protozoa. In Plasmodium falciparum, calcium-dependent protein …

Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …

The calcium ion (Ca2+) is used as a major signaling molecule in a diverse range of
eukaryotic cells including several human parasitic protozoa, such as Trypanosoma cruzi …

Abstract Calcium Dependent Protein Kinases are key effectors of calcium signaling in
malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum, but …

Ca2+ channels regulate many crucial processes within cells and their abnormal activity can
be damaging to cell survival, suggesting that they might represent attractive therapeutic …