Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …

The small heat shock proteins (sHSPs) and the related α-crystallins (αCs) are virtually
ubiquitous proteins that are strongly induced by a variety of stresses, but that also function …

INTRODUCTION Cells have evolved quality control mechanisms that operate under normal
growth conditions and during stress to maintain protein homeostasis (proteostasis) and …

Dysfunction of protein quality control contributes to the cellular pathology of polyglutamine
(polyQ) expansion diseases and other neurodegenerative disorders associated with …

All organisms sense and respond to environmental and physiological stress by inducing cell
stress responses that protect core biosynthetic processes such as DNA repair, protein …

The immune system of an organism is an essential component of the defense mechanism
aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed …

Bortezomib has shown great promise in the treatment of amyloid light-chain (AL)
amyloidosis. We present our experience of 43 patients with AL amyloidosis who received …

When proteostasis becomes unbalanced, unfolded proteins can accumulate and aggregate.
Here we report that the dye, tetraphenylethene maleimide (TPE-MI) can be used to measure …

Organisms survive changes in the environment by altering their rates of metabolism, growth,
and reproduction. At the same time, the system must ensure the stability and functionality of …

Accumulation of misfolded protein aggregates is a hallmark event in diverse diseases.
These structures are able to seed their own polymerization by acting as aggregation nuclei …