Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease
affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of …

Amyotrophic lateral sclerosis (ALS) is predominantly sporadic, but associated with heritable
genetic mutations in 5–10% of cases, including those in Cu/Zn superoxide dismutase …

Many mutations confer one or more toxic function (s) on copper/zinc superoxide dismutase 1
(SOD1) that impair motor neuron viability and cause familial amyotrophic lateral sclerosis …

The oxidative stress theory of aging predicts that manipulations that alter oxidative
stress/damage will alter aging. The gold standard for determining whether aging is altered is …

This work is devoted to the phenomenon of liquid-liquid phase separation (LLPS), which has
come to be recognized as fundamental organizing principle of living cells. We distinguish …

Genetic discoveries in ALS have a significant impact on deciphering molecular mechanisms
of motor neuron degeneration. The identification of SOD1 as the first genetic cause of ALS …

Ever since lysozyme was discovered by Fleming in 1922, this protein has emerged as a
model for investigations on protein structure and function. Over the years, several high …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that targets motor
neurons, leading to paralysis and death within a few years of disease onset. While several …

The unfolded protein response (UPR) is induced at symptom onset and disease end stage
in rodent models of familial amyotrophic lateral sclerosis (ALS) that express superoxide …